High Levels of beta-D-glucan in immunocompromised children with proven invasive fungal disease.
نویسندگان
چکیده
The plasmatic levels of 1,3-beta-d-glucan (BDG) were >523 pg/ml in 4 children, 2 low-birth-weight neonates and 2 stem cell transplant recipients, with the following invasive fungal diseases (IFD) proven apart from this BDG test: 3 cases of Candida parapsilosis candidemias and 1 case of disseminated aspergillosis. The BDG test may be useful for identification of IFD in pediatrics.
منابع مشابه
Beta-D-glucan detection as a diagnostic test for invasive aspergillosis in immunocompromised critically ill patients with symptoms of respiratory infection: an autopsy-based study.
Beta-(1,3)-D-glucan (BG) detection is an emerging tool to diagnose invasive fungal infections (IFIs). Invasive aspergillosis (IA) is the second most common IFI in immunocompromised intensive care unit (ICU) patients. We retrospectively analyzed the serum BG concentration (Fungitell; Associates of Cape Cod) in immunocompromised ICU patients with proven IA and in immunocompromised ICU patients in...
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متن کاملAssessment of Β-d-(1→3)-glucan Assay for Diagnosis of Invasive Fungal Infec- Tions
Aim: Invasive fungal infections (IFIs) are associated with high mortality and morbidity. However, the diagnosis of IFIs in an immunocompromised host is difficult and often missed or delayed. Our aim was to investigate the feasibility of the (1→3)-β-DGlucan assay as a diagnostic complement for IFIs. Methods: We reviewed the records of all inpatients in various units at Erciyes University’s Medic...
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TO THE EDITOR—A definitive diagnosis of invasive fungal infection (IFI) remains difficult in immunocompromised hosts. Thus, fungal markers such as galacto-mannan (GM) or (1-3)-β-D-glucan (BG) are useful for the diagnosis of probable IFI in high risk patients [1]. Detection of GM in cerebrospinal fluid (CSF) has been studied and is now considered diagnostic for central nervous system (CNS) asper...
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ورودعنوان ژورنال:
- Clinical and vaccine immunology : CVI
دوره 17 5 شماره
صفحات -
تاریخ انتشار 2010